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KMID : 1132720180160030071
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Genomics & Informatics
2018 Volume.16 No. 3 p.71 ~ p.74
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Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
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Park Jong-Lyul
Kim Seon-Kyu
Kim Jeong-Hwan
Yun Seok-Joong
Kim Wun-Jae
Kim Won-Tae
Jeong Pil-Du
Kang Ho-Won
Kim Seon-Young
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Abstract
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Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.
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KEYWORD
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castration-resistant prostate cancer, DNA variants, whole-genome sequencing
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